Ghana is seriously one of the safest places in Africa.
If you simply just maintain usual safety considerations and don't put yourself in an obviously unsafe position, you will find the country incredibly safe. Seriously, I was alone at night and someone walked past me with a machette. I didn't even bat an eye because I was so at peace with the people here, I knew he'd just been trimming some hedges or something.

For women? I know as a guy I shouldn't comment on what I think a girl is likely to experience, but I have gathered enough information to know regardless of gender this place is safe keeping in mind the unfortunate truth that any country on the planet is more dangerous as a woman than a man. I met 3 women and asked for their experience, all 3 vouched exactly the same thing. One (from Ireland, around 50) lives in Accra, another (from Estonia, around 23) had spent 3 months riding their bike around the country alone, and the third (from Germany, around 40) was working away from home in Busua (go here its amazing!).

It goes deeper than just avoiding unfortunate situations, I believe following the gut is always the right decision. There wasn't even any underlying anxiety or gut feeling, unlike Morocco, where I never faced danger but I had that feeling once or twice.

GET THE MTN SIM!
I know its silly to mention this so early but trust me you'll want to get this right, straight off the bat.
When collecting your bags you will be approached by sim retailers. Don't be afraid, they're legit. I had just arrived in Africa, I didn't know who to trust and who was trying to rip me off, but you can trust the airport people. You can trust everyone in Ghana for the most part. I was weary handing my passport over but its just protocol. The first 5 minutes off the plane reassured me when the retailer lady could tell I was obviously weary said: "You don't need to worry in Ghana, no one is out to get you!" Which I came to find very true.
Telecel and MTN are your only sim options.
MTN wins in every category, it's cheaper, more reliable and has more coverage.
I didn't know this and I bought a Telecel sim. Anywhere outside Accra will be a serious struggle to find reception. Don't worry if you’ve made the same mistake though! You can buy an MTN sim from any retailer, their shops are all around the country. See in the next section how to top-up because this is also important.

My rule for travel is just pay for the bloody taxi when you first land. Your exhausted and jetlagged, you have 25kg of luggage, you just want to rest, so it's seriously not worth the $10 in savings giving yourself a headache trying to figure out how the locals do it (which I discuss later!)

I suggest while your in the taxi, download Ioverlander. This is a lifesaver in Ghana, it's like a google maps but filled with local travel information, good restaurants, where to find ATM's, all the little bits and bobs that are difficult to figure out by yourself.

Theres actually tonnes of accommodation in Accra, but what young broke traveller can afford hotels these days? I've got 2 options here to keep you safe and comfortable while saving your money. Unless you want to spend the extra money in which case you will have to research yourself because that certainly wasn't what I did!

mostly stayed in Osu. It's nearest to all the action! Though if your like me thinking "what bloody action?" That's okay, you'll come to realise. I was a bit shocked at the prices for accommodation in Ghana (and the whole of West Africa actually), because of the scarcity of tourism, tourist amenities can actually be on the more pricey side, definitely not the kind of prices you'd see in SE Asia.

Africa Vibrations Hostel, Osu
This place has everything you need and is in a nicer and quieter area. It's safe and has a bed, heated shower, and toilets (and a cat!). Bare bones necesseties? Yes, but if you've been sleeping under bridges, on couches and in your tent like me, trust me, this place feels like luxury. The owners are a lovely Americal couple that are usually around, they'll answer any questions you may have as they know Accra like the ack of their hand. They have food options here too, but once your settled in you'll realise its cooler grabbing your own food from all the places around the hostel. There's also a laundry service, a bit on the pricey side and they lost a pair of my undies and socks too (and don't forget about Africa time, it's not too swift). I learned very quickly its not too difficult to find a bucket and do your own washing in the shower and hang it over the balcony.

Somewhere nice, near Accra New Town
I never stayed here, but it seemed the main options were between Vibrations and this one. The location isn't quite as good, but it has a pool and gets more tourists than Vibrations. It has all the same amenities too.

So what's there to do in Accra?
Hmmm…
Your in the bustling capital of Ghana that’s what! Seriously there isn't a whole lot of experiences you can do that you can't find elsewhere in the world. For the most part, Accra for me was all about getting my bearings and learning the ways of Ghana. There's not many attractions, epic restaurants, walking tours, or cool hideouts. The best thing to do in Accra is just be in Accra, experience the life of the Ghanians because it's THIS that you can't find anywhere else in the world. Talk to the friendly locals, eat with them, buy the handicrafts etc. this is where you really start to see the true beauty of the country.

This is one of those things that is super simple once you know, but you'd be kinda screwed if you didn't know. There are retailers everywhereeeeeee. Everyone has a phone these days so keeping connected as crucial here as anywhere else in the world. You'll see vendors literally everywhere, you just have to spot the brightly colours that either says MTN or Telecel, they are usually in a booth or sitting under an umbrella. But what is important to note is that these smaller vendours can't top up data most of the time, only talking and text (which through a confusing process can be transferred to data, I never figured that out though). Most of the time you can only buy data top-ups in a proper store, so you have to be smart and plan ahead to make sure you can get to a shop before your data runs out.
It's best to buy a big bulk package, I bought 400gb which was totally unnecessary but it was a meer 5 cedis more to get that over the 200gb package. I was 3 weeks into the trip and SICK of constantly having to visit the stores and top up my data.

This is always an interesting experience if your visiting Africa for the first time. Morocco has the bus, Mauritania has sept-place, Ghana has the tro-tro. How do you spot these beaten up vans? They usually have a sign up the front and a man constantly yelling out the window the destination/route. It's best to go to a designated stop or depot but once your confident enough you can usually flag them down and they'll pull over for you. The cost is usually around 3 cedis.
If your taking longer trips you will definitely want to find a bus depot. Whether your going 3 hours to Takoradi or 6 hours to Kumasi, they can pretty much always get you to where you want to go. Just look around until you see a sign with your destination on it, or ask someone, its really simple. Once you're accustomed to the layed back ways of Ghana you'll realise that the way they do things here is so simple that it's almost easier to get around than Western countries! You have to take your bike? No worries, we'll strap it on the back or the roof! The bus is full? No worries, we'll make space! Seriously, Ghana is a place of making shit happen.
My bus journeys included: Accra-Aburi, Ho-Amedzofe, Ho-Kumasi, Kumasi-Takoradi. With my bike and huge backpack I never found any issues except for someone overcharging me (what I like to call the Obroni price).

Other transport options include ride shares like uber, or the more local options are Yango and Bolt (Bold being the cheapest and most prominent).
Or just the good ol' fashion way of sticking your thumb out. Hitch-hiking isn't quite as prominent here as it is in other countries but it's always worth a shot if you want that experience. Once my bike broke and I asked a local, he managed strapped my bike and both my bags on the same motorbike we were riding and take me through the muddy, bumpy roads to the nearest town (this was far from comfortable but hey it saved my ass!)

Before I get started on the food scene: Water.
Don't buy bottled water! It's not unsafe or anything, but why spend 15-30 cedis on a bottle everytime when you can buy water sachets for just 1 cedi. Everyone needs to drink water so it's quite easy to find sachets anywhere you go. I was advised not to drink the tap or well water, I think your body needs to be seriously strong to drink the untreated stuff, most of the locals didn't even drink tap or well water.

Now,
What I learned is that the best places to eat don't look like what you'd expect a restaurant to be. What you want to look out for is a little stand, booth or shack with some big bowls, that’s it. I didn't realise this at first, I thought "well there's no seating out and I can't see a menu so…" But I was wrong! This is how they do things, just ask. They'll pull up a chair for you and prepare something delicious. If your staying in Osu, there's a heap of options within walking distance whether you want to cheat and have a white people meal or try the street stuff.

The food options are mostly jollof rice, fufu, waakye, banku, palava, or talapia fish (they also LOVE indomi here). They're all delicious! The Ghanians (to my surprise) are massive spice lovers too, just be prepared. Most stands work kind of like a pick and mix, They'll have a rice base, and a bunch of sides sitting out to choose from which normally includes fried chicken, boiled eggs, chilly, salad, spaghetti, mayo and tomato sauce. You just tell them something like "10 cedis worth of jollof, (then point), a little bit of this, little bit of that etc."

A fair warning!
Your stomach will 100% need to warm up to the cuisine here. I never got food poisoning in Ghana (that doesn't mean you will be this lucky) but there were some seriously long periods of having an upset gut. The food scene here is awesome, but you won't normally get fresh, off the grill sort of things SE Asia provides, most of the street food here has been sitting out in the sun all day, and is on the stale side and luke-warm (but still delicious!).

The most classic Ghanian dish you can get is fufu. I hate fufu. I tried to like it but I really couldn't stand eating it! Banku is a very similar dish which I enjoyed much more. Even though I didn't like it I would 100% recommend trying it, especially if your at a place where you can see the women preparing the dough fresh, that’s where you'll get the good stuff.

If your looking to truly find the local experience, get yourself on to couchsurfing. It's an app that allows tourists to stay for free in locals homes. It is a very safe practice, as there is a lot of safety measures they put in place. I couch surfed quite a lot in Ghana and it’s a really awesome experience. Most of the hosts are cool and down to Earth people who want to know more about other people and the world through meeting tourists and new people. All the hosts I stayed with were overwhelmingly kind and had beautifully caring souls.

Otherwise, Ioverlander is great for finding spots to camp and all the information that goes along with it.